Maryland is a U.S. state located in the Mid Atlantic region, bordering Virginia, West Virginia and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware to its east. According to the U.S. Census Bureau, Maryland has the highest median household income of any state, with a median income of $70,545. Maryland was the seventh state to ratify the United States Constitution, and three nicknames for it, the Old Line State, the Free State, and the Chesapeake Bay State are occasionally used.
Maryland is a major center for life sciences research and development. With more than 350 biotechnology companies located there, Maryland is the third-largest nexus in this field in the United States. Institutions and government agencies with an interest in research and development located in Maryland include the Johns Hopkins University, the Johns Hopkins Applied Physics Laboratory, more than one campus of the University System of Maryland, Goddard Space Flight Center, the United States Census Bureau, the National Institutes of Health (NIH), the National Institute of Standards and Technology (NIST), the National Institute of Mental Health (NIMH), the federal Food and Drug Administration (FDA), the Howard Hughes Medical Institute, the Celera Genomics company, Human Genome Sciences (HGS),the J. Craig Venter Institute (JCVI), and MedImmune - recently purchased by AstraZeneca.
Maryland has a wide array of climates for a state of its size. It depends on numerous variables, such as proximity to water, elevation, and protection from colder weather due to downslope winds. The eastern half of Maryland lies on the Atlantic Coastal Plain, with very flat topography and very sandy or muddy soil. This region has a humid subtropical climate, with hot, humid summers and a short, mild to cool winter. This region includes the cities of Salisbury, Annapolis, Ocean City, and southern and eastern greater Baltimore. Beyond this region lies the Piedmont which lies in the transition between the humid subtropical climate zone and the subtropical highland zone (Köppen Cfb), with hot, humid summers and cool winters where average annual snowfall exceeds 20 inches and temperatures below 10°F are annual occurrences. This region includes Frederick, Hagerstown, Westminster, Gaithersburg and northern and western greater Baltimore.
Extreme western Maryland, in the higher elevations of Allegany County and Garrett County lie completely in the subtropical highland (Köppen Cfb) zone, due to elevation (more typical of the Appalachian mountain region) with milder summers and cool, often snowy winters. Precipitation in the state is characteristic of the East Coast. Annual rainfall ranges from 35 to 45 inches (890 to 1,100 mm) with more in higher elevations. Nearly every part of Maryland receives 3.5–4.5 inches (89–110 mm) per month of rain. Average annual snowfall varies from 9 inches (23 cm) in the coastal areas to over 100 inches (250 cm) in the western mountains of the state. Because of its location near the Atlantic Coast, Maryland is somewhat vulnerable to tropical cyclones, although the Delmarva Peninsula, and the outer banks of North Carolina to the south provide a large buffer, such that a strike from a major hurricane (category 3 or above) is not very likely but is not impossible. More often, Maryland might get the remnants of a tropical system which has already come ashore and released most of its wind energy. Maryland averages around 30–40 days of thunderstorms a year, and averages around six tornado strikes annually.
Maryland possesses a great variety of topography, hence its nickname, "America in Miniature." It ranges from sandy dunes dotted with seagrass in the east, to low marshlands teeming with wildlife and large bald cypress near the bay, to gently rolling hills of oak forest in the Piedmont Region, and pine groves in the mountains to the west.
Maryland is bounded on its north by Pennsylvania, on its west by West Virginia, on its east by Delaware and the Atlantic Ocean, and on its south, across the Potomac River, by West Virginia and Virginia. The mid-portion of this border is interrupted on the Maryland side by Washington, DC, which sits on land that was originally part of Maryland. The Chesapeake Bay nearly bisects the state, and the counties east of the bay are known collectively as the Eastern Shore. Most of the state's waterways are part of the Chesapeake Bay watershed, with the exceptions of a tiny portion of extreme western Garrett County (drained by the Youghiogheny River as part of the watershed of the Mississippi River), the eastern half of Worcester County (which drains into Maryland's Atlantic coastal bays), and a small portion of the state's northeast corner (which drains into the Delaware River watershed). So prominent is the Chesapeake in Maryland's geography and economic life that there has been periodic agitation to change the state's official nickname to the Bay State, a nickname that has actually been used by Massachusetts for a long time.
The highest point in Maryland, with an elevation of 3,360 feet (1,020 m), is Hoye Crest on Backbone Mountain, in the southwest corner of Garrett County, near the border with West Virginia and near the headwaters of the North Branch of the Potomac River. Close to the small town of Hancock, in western Maryland, about two-thirds of the way across the state, there is only 1.83 miles (2.95 km) between its borders. This geographical curiosity makes Maryland the narrowest state, bordered by the Mason-Dixon Line to the north, and the northwards-arching Potomac River to the south.
Portions of Maryland are included in various official and unofficial geographic regions. For example, the Delmarva Peninsula is composed of the Eastern Shore counties of Maryland, the entire state of Delaware, and the two counties that make up the Eastern Shore of Virginia, whereas the westernmost counties of Maryland are considered part of Appalachia. Much of the Baltimore–Washington corridor lies just south of the Piedmont in the Coastal Plain, though it straddles the border between the two regions.
A quirk of the geography of Maryland is the absence of any natural lakes, though there are numerous ponds. During the latter Ice Ages, the glaciers did not reach as far south as Maryland, and therefore they did not carve out the deep natural lakes that exist in states farther north. There are numerous man-made lakes, the largest of these being the Deep Creek Lake, a reservoir in Garrett County in westernmost Maryland. The lack of a glacial history also accounts for Maryland's soil, which is sandier and muddier than the rocky soils farther to the north and northeast.

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